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The age at the final menstrual period holds intrinsic clinical and public health interest because the age at which natural menopause occurs may be a marker of aging and health. In addition, women who have undergone bilateral oophorectomy under the age of 45 years have been observed to be at increased risk of mortality from cardiovascular disease, particularly if they were not treated with estrogen. Although menopause is a universal phenomenon among women, the timing of the onset and the duration of the menopausal transition and the timing of the final menstrual period are not. Thus, until recently, much of the knowledge about the timing of the natural final menstrual period has been affected by the nature of the samples of women studied and a of other methodologic differences in the studies of this phenomenon, which must be considered in comparing and summarizing their .
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